The diagnostic utility of methylthioadenosine phosphorylase immunohistochemistry for pancreatic ductal adenocarcinoma in FNA and small biopsy specimens.

Sanhong YuLeona A DoyleJason L HornickJeffrey K Mito

Published in: Cancer cytopathology (2023)

Loss of MTAP was identified in approximately 30% of PDAC small biopsy specimens. As loss of MTAP expression is not expected in nonneoplastic cells, and these findings suggest that MTAP IHC can support a diagnosis of PDAC in small biopsy samples.

Keyphrases

fine needle aspiration
ultrasound guided
induced apoptosis
poor prognosis
cell cycle arrest
oxidative stress
cell proliferation
long non coding rna
endoplasmic reticulum stress
signaling pathway