Diagnostic accuracy of a sequence-specific Mtb -DNA hybridization assay in urine: a case-control study including subclinical TB cases.
Yves TschanMohamed SasamaloHellen HizaJacques FellaySébastien GagneuxKlaus ReitherJerry HellaDamien PortevinPublished in: Microbiology spectrum (2024)
that is shed in the urine of tuberculosis patients. We present accuracy data that would fulfill the target product profile for a non-sputum test. In addition, recent epidemiological data suggested that up to 50% of individuals secreting live bacilli do not present with symptoms at the time of screening. We report, here, that the investigated index test could also detect instances of asymptomatic TB infections among household contacts.
Keyphrases
- mycobacterium tuberculosis
- pulmonary tuberculosis
- end stage renal disease
- electronic health record
- ejection fraction
- newly diagnosed
- chronic kidney disease
- cystic fibrosis
- single molecule
- prognostic factors
- emergency department
- high throughput
- gram negative
- machine learning
- hiv aids
- multidrug resistant
- high resolution
- atomic force microscopy
- sleep quality
- physical activity
- antiretroviral therapy
- circulating tumor cells
- high speed