SARS-CoV-2 Induces Epithelial-Enteric Neuronal Crosstalk Stimulating VIP Release.

Arun BalasubramaniamPhilip R TedburySimon M MwangiYunshan LiuGe LiDidier MerlinAdam D GraczPeijian HeStefan G SarafianosShanthi Srinivasan

Published in: Biomolecules (2023)

Our findings demonstrate that SARS-CoV-2 enterocyte infection leads to ER stress and the release of DAMPs that up-regulates the expression and release of VIP by EN. VIP in turn inhibits fluid absorption through the downregulation of brush-border membrane expression of NHE3 in enterocytes. These data highlight the role of epithelial-enteric neuronal crosstalk in COVID-19-related diarrhea.

Keyphrases

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