Chemistry, Biological Activities, and Pharmacological Properties of Gastrodin: Mechanism Insights.
Naoual El MenyiyYoussef ElouafyRania MoubachirRhizlan AbdnimTaoufiq BenaliDouae TahaAsaad KhalidAshraf N AbdallaSiddiqa M A HamzaSalma Elhadi IbrahimMohamed El-ShazlyMuhammad Imran TousifAbdelhakim BouyahyaPublished in: Chemistry & biodiversity (2024)
Gastrodin, a bioactive compound derived from the rhizome of the orchid Gastrodia elata, exhibits a diverse range of biological activities. With documented neuroprotective, anti-inflammatory, antioxidant, anti-apoptotic, and anti-tumor effects, gastrodin stands out as a multifaceted therapeutic agent. Notably, it has demonstrated efficacy in protecting against neuronal damage and enhancing cognitive function in animal models of Alzheimer's disease, Parkinson's disease, and cerebral ischemia. Additionally, gastrodin showcases immunomodulatory effects by mitigating inflammation and suppressing the expression of inflammatory cytokines. Its cytotoxic activity involves the inhibition of angiogenesis, suppression of tumor growth, and induction of apoptosis. This comprehensive review seeks to elucidate the myriad potential effects of Gastrodin, delving into the intricate molecular mechanisms underpinning its pharmacological properties. The findings underscore the therapeutic potential of gastrodin in addressing various conditions linked to neuroinflammation and cancer.
Keyphrases
- cerebral ischemia
- oxidative stress
- anti inflammatory
- subarachnoid hemorrhage
- brain injury
- blood brain barrier
- cell death
- poor prognosis
- signaling pathway
- endothelial cells
- traumatic brain injury
- papillary thyroid
- squamous cell carcinoma
- climate change
- risk assessment
- inflammatory response
- human health
- cell cycle arrest
- squamous cell
- vascular endothelial growth factor
- lymph node metastasis
- cell proliferation
- long non coding rna