Are genes destiny? Exploring the role of intrauterine environment in moderating genetic influences on body mass.
Jinho KimPublished in: American journal of human biology : the official journal of the Human Biology Council (2019)
Genes are not destiny and environmental factors may offset the effects of obesity-promoting genes. Public health efforts to counteract genetic effects on body mass may begin as early as in utero. Efforts to prevent higher birth weight may thus help reduce the risk of obesity later in life, by directly addressing the programming effects of the in utero environment and also indirectly moderating obesity-promoting genetic effects.
Keyphrases
- genome wide
- weight gain
- birth weight
- insulin resistance
- metabolic syndrome
- public health
- weight loss
- high fat diet induced
- type diabetes
- dna methylation
- copy number
- bioinformatics analysis
- genome wide identification
- social support
- body mass index
- gestational age
- adipose tissue
- genome wide analysis
- gene expression
- depressive symptoms
- transcription factor