Combined effect of pancreatic lipid content and gene variants (TCF7L2, WFS1 and 11BHSD1) on B-cell function in Middle Aged Women in a Post Hoc Analysis.

Ákos NádasdiViktor GálTamás MassziAttila PatócsPeter IgazAnikó SomogyiGábor Firneisz

Published in: Diabetology & metabolic syndrome (2022)

The PNPLA3 rs738409 genotype has a major effect on the correlation between PTGC and HTGC. Furthermore we first report the combined effect of PTGC and individual risk gene variants of TCF7L2, WFS1 and 11ΒHSD1 on β-cell dysfunction. The correlation between pancreatic lipid accumulation and HbA1c also indicates an important role for the latter pathology.

Keyphrases

copy number
middle aged
genome wide
single cell
polycystic ovary syndrome
cell therapy
oxidative stress
stem cells
gene expression
fatty acid
genome wide analysis