A novel high-prevalence antigen in the Lutheran system, LUGA (LU24), and an updated, full-length 3D BCAM model.

Aline FlochChristine Lomas-FrancisSunitha VegeSteven BrennanGayane ShakarianAlexandre G De Brevern Connie M Westhoff

Published in: Transfusion (2023)

The c.212G > A change results in the loss of LUGA (LU24) antigen. Whole genome sequencing continues to reveal polymorphisms with uncertain immunogenicity. This model and demonstration that nearly all residues associated with the expression of a Lutheran antigen are exposed will help evaluate the significance of new polymorphisms.

Keyphrases

poor prognosis
risk factors
genome wide
gene expression
long non coding rna
dna methylation