Alpha-1 antitrypsin governs alcohol-related liver disease in mice and humans.

Christoph GranderBenedikt SchaeferJulian SchwärzlerFelix GrabherrDennis M de GraafBarbara EnrichGeorg OberhuberLisa MayrMoris SanginetoNikolai JaschkeTimon E AdolphMaria EffenbergerAlexander R MoschenCharles A DinarelloHeinz ZollerHerbert Tilg

Published in: Gut (2020)

Cirrhotic ALD patients with AAT concentrations less than 120 mg/dL displayed an increased risk for death/liver transplantation. Both hAAT-Tg mice and AAT-treated wt animals showed protection from ethanol-induced liver injury. AAT could reflect a treatment option for human ALD, especially for alcoholic hepatitis.

Keyphrases

high fat diet induced
endothelial cells
liver injury
wild type
drug induced
pluripotent stem cells