Bone marrow adipocytes enhance osteolytic bone destruction by activating 1q21.3(S100A7/8/9-IL6R)-TLR4 pathway in lung cancer.
Guojing LuoMengjia TangQian ZhaoLingyun LuYing XieYujue LiChang LiuLi TianXiang ChenXijie YuPublished in: Journal of cancer research and clinical oncology (2020)
Our study suggested that bone marrow adipocyte may communicate with lung cancer cells via 1q21.3 (S100A8/A9-IL6R)-TLR4 pathway to promote osteolytic bone destruction. 1q21.3 (S100A8/A9-IL6R) is a potential target for the treatment of lung cancer bone metastasis.
Keyphrases
- bone marrow
- bone mineral density
- mesenchymal stem cells
- toll like receptor
- adipose tissue
- inflammatory response
- soft tissue
- bone loss
- bone regeneration
- postmenopausal women
- signaling pathway
- insulin resistance
- type diabetes
- risk assessment
- metabolic syndrome
- fatty acid
- skeletal muscle
- human health
- replacement therapy