Do sputum or circulating blood samples reflect the pulmonary transcriptomic differences of COPD patients? A multi-tissue transcriptomic network META-analysis.
Rosa FanerJarrett D MorrowSandra Casas-RecasensSuzanne M CloonanGuillaume NoellAlejandra López-GiraldoRuth Tal-SingerBruce E MillerEdwin K SilvermanAlvar AgustíCraig P HershPublished in: Respiratory research (2019)
These observations indicate that major differences in lung tissue transcriptomics in patients with COPD are poorly mirrored in sputum and are unrelated to those determined in blood, suggesting that the systemic component in COPD is independently regulated. Finally, the fact that one of the preserved modules associated with FEV1 was enriched in mitochondria-related genes supports a role for mitochondrial dysfunction in the pathobiology of COPD.
Keyphrases
- chronic obstructive pulmonary disease
- lung function
- cystic fibrosis
- single cell
- systematic review
- mycobacterium tuberculosis
- newly diagnosed
- ejection fraction
- pulmonary tuberculosis
- pulmonary hypertension
- rna seq
- air pollution
- transcription factor
- cell death
- randomized controlled trial
- patient reported outcomes
- meta analyses
- reactive oxygen species
- patient reported