Nickel-Catalyzed C sp2 -OMe Functionalization for Chemoselective Aromatic Homologation En Route to Nanographenes.
Lorena CapdevilaJudith SalaHarry L AndersonXavi RibasPublished in: Chemistry (Weinheim an der Bergstrasse, Germany) (2022)
A Ni-catalyzed C sp2 -OMe ortho-functionalization methodology to form chemoselectively alkyne monoannulation or aromatic homologation products is reported as a novel protocol towards the valorisation of substrates containing C sp2 -OMe units. Double activation of C sp2 -OMe and C sp2 -F bonds is also demonstrated. Further use of aromatic homologation products towards the synthesis of nanographene-like compounds is described.