Noninvasive detection of pancreatic ductal adenocarcinoma using the methylation signature of circulating tumour DNA.

Huanwen WuShiwei GuoXiaoding LiuYatong LiZhixi SuQiye HeXiaoqian LiuZhiwen ZhangLianyuan YuXiaohan ShiSuizhi GaoHuan WangYaqi PanChengcheng MaRui LiuMenghua DaiGang JinZhiyong Liang

Published in: BMC medicine (2022)

The PDACatch assay demonstrated high sensitivity for early PDAC plasma, providing potential utility for noninvasive detection of early PDAC and indicating the effectiveness of methylation haplotype analyses in discovering robust cancer markers.

Keyphrases

loop mediated isothermal amplification
dna methylation
genome wide
randomized controlled trial
label free
real time pcr
systematic review
circulating tumor
high throughput
single molecule
squamous cell
squamous cell carcinoma
climate change
human health
sensitive detection