HMGB1/TLR4 Signaling Affects Regulatory T Cells in Acute Lung Injury.

Min ZhouYadi ZhangRui TangHaiyan LiuMin DuZhi GaoZongshu JiHaoshu Fang

Published in: Journal of inflammation research (2021)

In HMGB1-induced lung injury, HMGB1 affects the expression of FOXP3 and CTLA-4 through TLR4, thus reducing the immunosuppressive function of Treg cells.

Keyphrases

regulatory t cells
inflammatory response
toll like receptor
dendritic cells
immune response
lipopolysaccharide induced
induced apoptosis
poor prognosis
lps induced
cell cycle arrest
high glucose
diabetic rats
nuclear factor
binding protein
drug induced