Deciphering the Role of PGRMC1 During Human Decidualization Using an In Vitro Approach.

Stefania Salsano Roberto González-MartínAlicia QuiñoneroSilvia Pérez-Debén Francisco Domínguez

Published in: The Journal of clinical endocrinology and metabolism (2021)

Our findings associate PGRMC1 to hormonal biosynthesis, metabolism, and vesicular transport-important cellular functions for dEnSC supporting pregnancy. Activation of membrane P4 receptor signaling alone was unable to induce downstream effects needed for proper decidualization.

Keyphrases

endothelial cells
induced pluripotent stem cells
pluripotent stem cells
polycystic ovary syndrome
pregnancy outcomes
metabolic syndrome
adipose tissue
insulin resistance