Isolation and characterization of antibody fragments selective for human FTD brain derived TDP-43 variants.
Lalitha VenkataramanPing HeGalam KhanBrent T HarrisMichael R SierksPublished in: BMC neuroscience (2020)
These results show existence of different disease specific TDP variants in FTD individuals. We have identified a panel of scFvs capable of recognizing these disease specific TDP variants in postmortem FTD tissue and sera samples over age matched controls and can thus serve as a biomarker tool.