Trastuzumab upregulates programmed death ligand-1 expression through interaction with NK cells in gastric cancer.
Kohei YamashitaMasaaki IwatsukiNoriko Yasuda-YoshiharaTakeshi MorinagaYosuke NakaoKazuto HaradaKojiro EtoJunji KurashigeYukiharu HiyoshiTakatsugu IshimotoYohei NagaiShiro IwagamiYoshifumi BabaYuji MiyamotoNaoya YoshidaJaffer A AjaniHideo BabaPublished in: British journal of cancer (2020)
Tmab can upregulate PD-L1 expression on GC cells through interaction with NK cells. These results suggest clinical implications in the assessment of the predictive significance of PD-L1 expression for PD-1 inhibitors.