Comprehensive analysis of the efficacy and safety of CAR T-cell therapy in patients with relapsed or refractory B-cell acute lymphoblastic leukaemia: a systematic review and meta-analysis.

Sebastian Emmanuel WillyantoYohanes Audric AlimsjahKrisanto Tanjaya Aekkachai Tuekprakhon Aulia Rahmi Pawestri

Published in: Annals of medicine (2024)

Choosing a more efficacious and safer CAR T-cell treatment is crucial for improving overall survival in acute leukaemia. Beyond the promising anti-CD22 CAR T-cell, exploring costimulatory domains and new CD targets could enhance treatment effectiveness for r/r B-ALL.

Keyphrases

cell therapy
liver failure
randomized controlled trial
respiratory failure
acute lymphoblastic leukemia
stem cells
systematic review
acute myeloid leukemia
drug induced
combination therapy
hodgkin lymphoma
extracorporeal membrane oxygenation
acute respiratory distress syndrome