Epigenetic Induction of Cancer-Testis Antigens and Endogenous Retroviruses at Single-Cell Level Enhances Immune Recognition and Response in Glioma.
Thomas J LaiLu SunKevin LiTerry J PrinsJanet TregerTie LiMatthew Z SunDavid A NathansonLinda M LiauAlbert LaiRobert M PrinsRichard G EversonPublished in: Cancer research communications (2024)
This study dissects the tumor-intrinsic epigenetic and transcriptional mechanisms underlying enhanced T-cell functionality targeting decitabine-induced cancer-testis antigens in glioma. Our findings demonstrate concomitant induction of tumor antigens, reactivation of human endogenous retroviruses, and stimulation of interferon signaling as a mechanistic rationale to epigenetically prime human gliomas to immunotherapeutic targeting.
Keyphrases
- endothelial cells
- dendritic cells
- papillary thyroid
- gene expression
- single cell
- dna methylation
- squamous cell
- high glucose
- induced pluripotent stem cells
- pluripotent stem cells
- cancer therapy
- clinical trial
- acute myeloid leukemia
- rna seq
- diabetic rats
- transcription factor
- lymph node metastasis
- oxidative stress
- young adults
- high throughput
- long noncoding rna
- drug induced