High-throughput mRNA-seq atlas of human placenta shows vast transcriptome remodeling from first to third trimester.
Tania L GonzalezSahar WertheimerAmy E FlowersYizhou WangChintda SantiskulvongEkaterina L ClarkCaroline A JefferiesKate LawrensonJessica L ChanNikhil V JoshiYazhen ZhuHsian-Rong TsengS Ananth KarumanchiJohn WilliamsMargareta D PisarskaPublished in: bioRxiv : the preprint server for biology (2023)
This is the largest mRNA atlas of healthy human placenta across gestation, controlling for genetic and environmental factors, demonstrating substantial changes from first to third trimester in chorionic villi. Specific differences and stably expressed genes may be used to understand the specific role of the chorionic villi throughout gestation and develop first trimester biomarkers of placental health that transpire across gestation, which can be used for future development of biomarkers in maternal-fetal disease.
Keyphrases
- single cell
- gestational age
- genome wide
- endothelial cells
- high throughput
- preterm infants
- rna seq
- birth weight
- preterm birth
- induced pluripotent stem cells
- healthcare
- mental health
- gene expression
- binding protein
- pluripotent stem cells
- body mass index
- dna methylation
- health information
- pregnant women
- social media
- risk assessment
- transcription factor
- weight gain
- weight loss