Genistein stimulates insulin sensitivity through gut microbiota reshaping and skeletal muscle AMPK activation in obese subjects.
Martha Guevara-CruzEinar T Godinez-SalasMonica Sanchez-TapiaGonzalo Torres-VillalobosEdgar Pichardo-OntiverosRocio Guizar-HerediaLiliana Arteaga-SanchezGerardo GambaRaul Mojica-EspinosaAlejandro Schcolnik-CabreraOmar GranadosAdriana López-BarradasAriana Vargas-CastilloTorre-Villalvazo IvánLilia G NoriegaNimbe TorresArmando R TovarPublished in: BMJ open diabetes research & care (2020)
Change in the gut microbiota was accompanied by an improvement in insulin resistance and an increase in skeletal muscle fatty acid oxidation. Therefore, genistein could be used as a part of dietary strategies to control the abnormalities associated with obesity, particularly insulin resistance; however, long-term studies are needed.