A Four-Chemokine Signature Is Associated with a T-cell-Inflamed Phenotype in Primary and Metastatic Pancreatic Cancer.
Joan M RomeroBarbara T GrünwaldGun-Ho JangPrashant P BaviAaditeya JhaveriMehdi MasoomianSandra E FischerAmy ZhangRobert E DenrocheIllinca M LunguAngela De LucaJohn M S BartlettJing XuNiandong LiSharon DhaliwalSheng-Ben LiangDianne ChadwickForam VyasPeter BronsertSanjay SawTracy L McGahaFaiyaz NottaPamela S OhashiSusan J DoneGrainne M O'KaneJulie M WilsonJennifer J KnoxAshton ConnorYifan WangGeorge ZogopoulosSteven GallingerPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)
A conserved 4-chemokine signature marks resectable and metastatic PDAC tumors with an active antitumor phenotype. This could have implications for the appropriate selection of PDAC patients in immunotherapy trials.