Pamela S Ohashi

ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 30

Top Venues

Journal of immunology (Baltimore, Md. : 1950)

Cancer discovery

Clinical cancer research : an official journal of the American Association for Cancer Research

Nature communications

University of Toronto

University of Toronto (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Toronto Oct 01 2013

Canada

Cross appointment :: Medicine

Ontario Cancer Institute Nov 01 2009

Canada

Director :: Immune Therapy Program

Campbell Family Institute for Breast Cancer Research Aug 01 2007

Canada

Co-Director

Campbell Family Institute for Breast Cancer Research Jun 01 2004

Canada

Senior Scientist

University of Toronto Jul 01 2001

Canada

Full Professor

University of Toronto Jan 01 1993

Canada

Cross Appointment :: Immunology

Ontario Cancer Institute Mar 01 1992

Canada

Senior Scientist

University of Toronto Jul 01 1996 - Jul 01 2001

Canada

Associate Professor

University of Toronto Jan 01 1992 - Jan 01 1996

Canada

Assistant Professor :: Medical Biophysics

Education History

University of Toronto May 01 1984 - Jan 01 1988

Canada

PHD :: Immunology - Prof. T. Mak lab

York University Sep 01 1978 - Jun 01 1982

Canada

BSC

Publications

Eric Y Zhao, Enrique Sanz-Garcia, Zhihui Amy Liu, Derek Wong, Kayla Marsh, Albiruni Abdul Razak, Anna Spreafico, Philippe L Bedard, Aaron Richard Hansen, Stéphanie Lheureux, Dax Torti, Bernard Lam, Shih Yu Cindy Yang, Justin M Burgener, Ping Luo, Yong Zeng, Nicholas Cheng, Phillip Awadalla, Scott V Bratman, Pamela S Ohashi, Trevor J Pugh, Lillian L Siu
Early Changes in Tumor-Naive Cell-Free Methylomes and Fragmentomes Predict Outcomes in Pembrolizumab-Treated Solid Tumors. Cancer discovery 14 (6) (2024)
Eric Y Zhao, Enrique Sanz-Garcia, Zhihui Amy Liu, Derek Wong, Kayla Marsh, Albiruni Abdul Razak, Anna Spreafico, Philippe L Bedard, Aaron Richard Hansen, Stéphanie Lheureux, Dax Torti, Bernard Lam, Shih Yu Cindy Yang, Justin M Burgener, Ping Luo, Yong Zeng, Nicholas Cheng, Phillip Awadalla, Scott V Bratman, Pamela S Ohashi, Trevor J Pugh, Lillian L Siu
Early Changes in Tumor-Naive Cell-Free Methylomes and Fragmentomes Predict Outcomes in Pembrolizumab-Treated Solid Tumors. Cancer discovery 14 (6) (2024)
Douglas C Chung, Carlos R Garcia-Batres, Douglas G Millar, Stephanie W Y Wong, Alisha R Elford, Jessica A Mathews, Ben X Wang, Linh T Nguyen, Patricia A Shaw, Blaise A Clarke, Marcus Q Bernardini, Adrian G Sacher, Sarah Q Crome, Pamela S Ohashi
Generation of an Inhibitory NK Cell Subset by TGF-β1/IL-15 Polarization. Journal of immunology (Baltimore, Md. : 1950) 212 (12) (2024)
Douglas C Chung, Maryam Ghaedi, Kathrin Warner, Azin Sayad, Samuel D Saibil, Marcus Q Bernardini, Blaise A Clarke, Patricia A Shaw, Marcus O Butler, Alexandra Easson, A Sorana Morrissy, Ben X Wang, Linh Nguyen, Pamela S Ohashi, Jacquelot N
Characterization of innate lymphoid cell subsets infiltrating melanoma and epithelial ovarian tumors. Oncoimmunology 13 (1) (2024)
Eric Y Zhao, Enrique Sanz-Garcia, Zhihui Amy Liu, Derek Wong, Kayla Marsh, Albiruni Abdul Razak, Anna Spreafico, Philippe L Bedard, Aaron Richard Hansen, Stéphanie Lheureux, Dax Torti, Bernard Lam, Shih Yu Cindy Yang, Justin M Burgener, Ping Luo, Yong Zeng, Nicholas Cheng, Phillip Awadalla, Scott V Bratman, Pamela S Ohashi, Trevor J Pugh, Lillian L Siu
Early Changes in Tumor-Naive Cell-Free Methylomes and Fragmentomes Predict Outcomes in Pembrolizumab-Treated Solid Tumors. Cancer discovery 14 (6) (2024)
Douglas C Chung, Maryam Ghaedi, Kathrin Warner, Azin Sayad, Samuel D Saibil, Marcus Q Bernardini, Blaise A Clarke, Patricia A Shaw, Marcus O Butler, Alexandra Easson, A Sorana Morrissy, Ben X Wang, Linh Nguyen, Pamela S Ohashi, Jacquelot N
Characterization of innate lymphoid cell subsets infiltrating melanoma and epithelial ovarian tumors. Oncoimmunology 13 (1) (2024)
Scott C Lien, Dalam Ly, S Y Cindy Yang, Ben X Wang, Derek L Clouthier, Michael St Paul, Ramy Gadalla, Babak Noamani, Carlos R Garcia-Batres, Sarah Boross-Harmer, Philippe L Bedard, Trevor J Pugh, Anna Spreafico, Naoto Hirano, Albiruni R A Razak, Pamela S Ohashi
Tumor reactive γδ T cells contribute to a complete response to PD-1 blockade in a Merkel cell carcinoma patient. Nature communications 15 (1) (2024)
Douglas C Chung, Carlos R Garcia-Batres, Douglas G Millar, Stephanie W Y Wong, Alisha R Elford, Jessica A Mathews, Ben X Wang, Linh T Nguyen, Patricia A Shaw, Blaise A Clarke, Marcus Q Bernardini, Adrian G Sacher, Sarah Q Crome, Pamela S Ohashi
Generation of an Inhibitory NK Cell Subset by TGF-β1/IL-15 Polarization. Journal of immunology (Baltimore, Md. : 1950) 212 (12) (2024)
Douglas C Chung, Carlos R Garcia-Batres, Douglas G Millar, Stephanie W Y Wong, Alisha R Elford, Jessica A Mathews, Ben X Wang, Linh T Nguyen, Patricia A Shaw, Blaise A Clarke, Marcus Q Bernardini, Adrian G Sacher, Sarah Q Crome, Pamela S Ohashi
Generation of an Inhibitory NK Cell Subset by TGF-β1/IL-15 Polarization. Journal of immunology (Baltimore, Md. : 1950) 212 (12) (2024)
Alberto Hernando-Calvo, S Y Cindy Yang, Maria Vila-Casadesús, Ming Han, Zhihui Amy Liu, A Hal K Berman, Anna Spreafico, Albiruni Abdul Razak, Stéphanie Lheureux, Aaron Richard Hansen, Deborah Lo Giacco, Farnoosh Abbas-Aghababazadeh, Judith Matito, Benjamin Haibe-Kains, Trevor J Pugh, Scott V Bratman, Meenakshi Malhotra, Roger Berche, Omar Saavedra, Elena Garralda, Sawako Elston, Lillian L Siu, Pamela S Ohashi, Ana Vivancos, Philippe L Bedard
Combined Transcriptome and Circulating Tumor DNA Longitudinal Biomarker Analysis Associates With Clinical Outcomes in Advanced Solid Tumors Treated With Pembrolizumab. JCO precision oncology 8 (2024)
Scott C Lien, Dalam Ly, S Y Cindy Yang, Ben X Wang, Derek L Clouthier, Michael St Paul, Ramy Gadalla, Babak Noamani, Carlos R Garcia-Batres, Sarah Boross-Harmer, Philippe L Bedard, Trevor J Pugh, Anna Spreafico, Naoto Hirano, Albiruni R A Razak, Pamela S Ohashi
Tumor reactive γδ T cells contribute to a complete response to PD-1 blockade in a Merkel cell carcinoma patient. Nature communications 15 (1) (2024)
Alberto Hernando-Calvo, S Y Cindy Yang, Maria Vila-Casadesús, Ming Han, Zhihui Amy Liu, A Hal K Berman, Anna Spreafico, Albiruni Abdul Razak, Stéphanie Lheureux, Aaron Richard Hansen, Deborah Lo Giacco, Farnoosh Abbas-Aghababazadeh, Judith Matito, Benjamin Haibe-Kains, Trevor J Pugh, Scott V Bratman, Meenakshi Malhotra, Roger Berche, Omar Saavedra, Elena Garralda, Sawako Elston, Lillian L Siu, Pamela S Ohashi, Ana Vivancos, Philippe L Bedard
Combined Transcriptome and Circulating Tumor DNA Longitudinal Biomarker Analysis Associates With Clinical Outcomes in Advanced Solid Tumors Treated With Pembrolizumab. JCO precision oncology 8 (2024)
Eric Y Zhao, Enrique Sanz-Garcia, Zhihui Amy Liu, Derek Wong, Kayla Marsh, Albiruni Abdul Razak, Anna Spreafico, Philippe L Bedard, Aaron Richard Hansen, Stéphanie Lheureux, Dax Torti, Bernard Lam, Shih Yu Cindy Yang, Justin M Burgener, Ping Luo, Yong Zeng, Nicholas Cheng, Phillip Awadalla, Scott V Bratman, Pamela S Ohashi, Trevor J Pugh, Lillian L Siu
Early changes in tumor-naive cell-free methylomes and fragmentomes predict outcomes in pembrolizumab-treated solid tumors. Cancer discovery (2024)
Scott C Lien, Dalam Ly, S Y Cindy Yang, Ben X Wang, Derek L Clouthier, Michael St Paul, Ramy Gadalla, Babak Noamani, Carlos R Garcia-Batres, Sarah Boross-Harmer, Philippe L Bedard, Trevor J Pugh, Anna Spreafico, Naoto Hirano, Albiruni R A Razak, Pamela S Ohashi
Tumor reactive γδ T cells contribute to a complete response to PD-1 blockade in a Merkel cell carcinoma patient. Nature communications 15 (1) (2024)
Douglas C Chung, Carlos R Garcia-Batres, Douglas G Millar, Stephanie W Y Wong, Alisha R Elford, Jessica A Mathews, Ben X Wang, Linh T Nguyen, Patricia A Shaw, Blaise A Clarke, Marcus Q Bernardini, Adrian G Sacher, Sarah Q Crome, Pamela S Ohashi
Generation of an Inhibitory NK Cell Subset by TGF-β1/IL-15 Polarization. Journal of immunology (Baltimore, Md. : 1950) 212 (12) (2024)
Douglas C Chung, Carlos R Garcia-Batres, Douglas G Millar, Stephanie W Y Wong, Alisha R Elford, Jessica A Mathews, Ben X Wang, Linh T Nguyen, Patricia A Shaw, Blaise A Clarke, Marcus Q Bernardini, Adrian G Sacher, Sarah Q Crome, Pamela S Ohashi
Generation of an Inhibitory NK Cell Subset by TGF-β1/IL-15 Polarization. Journal of immunology (Baltimore, Md. : 1950) (2024)
Anirban Das, Uri Tabori, Lauren C Sambira Nahum, Natalie B Collins, Rebecca J Deyell, Rina Dvir, Cecile Faure Conter, Timothy Eg Hassall, Jane E Minturn, Melissa Edwards, Elissa Brookes, Vanessa Bianchi, Adrian B Levine, Simone Cardozo Stone, Sumedha Sudhaman, Santiago Sánchez-Ramírez, Ayse Bahar Ercan, Lucie K Stengs, Jiil Chung, Logine Negm, Gad A Getz, Yosef E Maruvka, Birgit Betina Ertl-Wagner, Pamela S Ohashi, Trevor J Pugh, Cynthia Hawkins, Eric Bouffet, Daniel A Morgenstern
Efficacy of nivolumab in pediatric cancers with high mutation burden and mismatch-repair deficiency. Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
SeongJun Han, Zhe Qi Liu, Douglas C Chung, Michael St Paul, Carlos R Garcia-Batres, Azin Sayad, Alisha R Elford, Matthew J Gold, Natasha Grimshaw, Pamela S Ohashi
Overproduction of IFNγ by Cbl-b-Deficient CD8+ T Cells Provides Resistance against Regulatory T Cells and Induces Potent Antitumor Immunity. Cancer immunology research 10 (4) (2022)
Ioannis D Dimitriou, David Meiri, Yulia Jitkova, Alisha R Elford, Marianne Koritzinsky, Aaron D Schimmer, Pamela S Ohashi, Nahum Sonenberg, Robert Rottapel
Translational Control by 4E-BP1/2 Suppressor Proteins Regulates Mitochondrial Biosynthesis and Function during CD8 + T Cell Proliferation. Journal of immunology (Baltimore, Md. : 1950) 208 (12) (2022)
Brittany B Campbell, Melissa A Galati, Simone C Stone, Alexandra N Riemenschneider, Melissa Edwards, Sumedha Sudhaman, Robert Siddaway, Martin Komosa, Nuno Miguel Nunes, Liana Nobre, A Sorana Morrissy, Matthew Zatzman, Michal Zapotocky, Lazar Joksimovic, Sangeetha N Kalimuthu, David Samuel, Gary Mason, Eric Bouffet, Daniel A Morgenstern, Melyssa Aronson, Carol Durno, David Malkin, John M Maris, Michael D Taylor, Adam Shlien, Trevor J Pugh, Pamela S Ohashi, Cynthia E Hawkins, Uri Tabori
Mutations in the RAS/MAPK Pathway Drive Replication Repair-Deficient Hypermutated Tumors and Confer Sensitivity to MEK Inhibition. Cancer discovery 11 (6) (2021)
Joan M Romero, Barbara T Grünwald, Gun-Ho Jang, Prashant P Bavi, Aaditeya Jhaveri, Mehdi Masoomian, Sandra E Fischer, Amy Zhang, Robert E Denroche, Illinca M Lungu, Angela De Luca, John M S Bartlett, Jing Xu, Niandong Li, Sharon Dhaliwal, Sheng-Ben Liang, Dianne Chadwick, Foram Vyas, Peter Bronsert, Sanjay Saw, Tracy L McGaha, Faiyaz Notta, Pamela S Ohashi, Susan J Done, Grainne M O'Kane, Julie M Wilson, Jennifer J Knox, Ashton Connor, Yifan Wang, George Zogopoulos, Steven Gallinger
A Four-Chemokine Signature Is Associated with a T-cell-Inflamed Phenotype in Primary and Metastatic Pancreatic Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 26 (8) (2020)
Charles W Tran, Matthew J Gold, Carlos Garcia-Batres, Kelly Tai, Alisha R Elford, Megan E Himmel, Andrew J Elia, Pamela S Ohashi
Hypoxia-inducible factor 1 alpha limits dendritic cell stimulation of CD8 T cell immunity. PloS one 15 (12) (2020)
Qingchuan Zhao, Jean-Philippe Laverdure, Joël Lanoix, Chantal Durette, Caroline Côté, Éric Bonneil, Céline M Laumont, Patrick Gendron, Krystel Vincent, Mathieu Courcelles, Sébastien Lemieux, Douglas G Millar, Pamela S Ohashi, Pierre Thibault, Claude Perreault
Proteogenomics Uncovers a Vast Repertoire of Shared Tumor-Specific Antigens in Ovarian Cancer. Cancer immunology research 8 (4) (2020)
Michael St Paul, Samuel D Saibil, Scott C Lien, SeongJun Han, Azin Sayad, David T Mulder, Carlos R Garcia-Batres, Alisha R Elford, Kavita Israni-Winger, Céline Robert-Tissot, Michael Zon, Sarah Rachel Katz, Patricia A Shaw, Blaise A Clarke, Marcus Q Bernardini, Linh T Nguyen, Benjamin Haibe-Kains, Trevor J Pugh, Pamela S Ohashi
IL6 Induces an IL22+ CD8+ T-cell Subset with Potent Antitumor Function. Cancer immunology research 8 (3) (2020)
Heather L MacGregor, Azin Sayad, Andrew Elia, Ben X Wang, Sarah Rachel Katz, Patricia A Shaw, Blaise A Clarke, Sarah Q Crome, Celine Robert-Tissot, Marcus Q Bernardini, Linh T Nguyen, Pamela S Ohashi
High expression of B7-H3 on stromal cells defines tumor and stromal compartments in epithelial ovarian cancer and is associated with limited immune activation. Journal for immunotherapy of cancer 7 (1) (2019)
Kea Martin, Ratiba Touil, Yeter Kolb, Grozdan Cvijetic, Kiichi Murakami, Laura Israel, Fernanda Duraes, David Buffet, Anton Glück, Satoru Niwa, Marc Bigaud, Tobias Junt, Natasa Zamurovic, Philip Smith, Kathy D McCoy, Pamela S Ohashi, Frédéric Bornancin, Thomas Calzascia
Malt1 Protease Deficiency in Mice Disrupts Immune Homeostasis at Environmental Barriers and Drives Systemic T Cell-Mediated Autoimmunity. Journal of immunology (Baltimore, Md. : 1950) 203 (11) (2019)
Samuel D Saibil, Michael St Paul, Robert C Laister, Carlos R Garcia-Batres, Kavita Israni-Winger, Alisha R Elford, Natasha Grimshaw, Céline Robert-Tissot, Dominic Guy Roy, Russell G Jones, Linh T Nguyen, Pamela S Ohashi
Activation of Peroxisome Proliferator-Activated Receptors α and δ Synergizes with Inflammatory Signals to Enhance Adoptive Cell Therapy. Cancer research 79 (3) (2018)
Sarah Q Crome, Pamela S Ohashi
Immunoregulatory functions of innate lymphoid cells. Journal for immunotherapy of cancer 6 (1) (2018)
Aras Toker, Linh T Nguyen, Simone Cardozo Stone, S Y Cindy Yang, Sarah Rachel Katz, Patricia A Shaw, Blaise A Clarke, Danny Ghazarian, Ayman Al-Habeeb, Alexandra M Easson, Wey L Leong, David R McCready, Michael Reedijk, Cynthia J Guidos, Trevor J Pugh, Marcus Q Bernardini, Pamela S Ohashi
Regulatory T Cells in Ovarian Cancer Are Characterized by a Highly Activated Phenotype Distinct from that in Melanoma. Clinical cancer research : an official journal of the American Association for Cancer Research 24 (22) (2018)
Charles W Tran, Samuel D Saibil, Thierry Le Bihan, Sara R Hamilton, Karl S Lang, Han You, Samuel D Saibil, Kristine M Garza, Alisha R Elford, Kelly Tai, Michael E Parsons, Kip Wigmore, Mitchell G Vainberg, Josef M Penninger, James R Woodgett, Tak W Mak, Pamela S Ohashi
Glycogen Synthase Kinase-3 Modulates Cbl-b and Constrains T Cell Activation. Journal of immunology (Baltimore, Md. : 1950) 199 (12) (2017)

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Publication Activity (10 Years)

Top Topics

Top Venues

Pamela S Ohashi