Induction of LEF1 by MYC activates the WNT pathway and maintains cell proliferation.

Yi-Heng HaoM Carmen Lafita-NavarroLauren ZachariasNofit Borenstein-AuerbachMin KimSpencer BarnesJiwoong KimJerry ShayRalph J DeBerardinisMaralice Conacci-Sorrell

Published in: Cell communication and signaling : CCS (2019)

We demonstrated that MYC is a transcriptional regulator of LEF1 in colonic cells. Our work proposes a novel pathway by which MYC regulates proliferation through activating LEF1 expression which in turn activates the WNT pathway.

Keyphrases

cell proliferation
transcription factor
signaling pathway
stem cells
induced apoptosis
poor prognosis
gene expression
cell cycle
cell cycle arrest
sensitive detection
oxidative stress
living cells
fluorescent probe
heat shock