Antagonism among DUX family members evolved from an ancestral toxic single homeodomain protein.

Darko Bosnakovski Erik A TosoElizabeth T EnerMicah D GearhartLulu YinFelipe F LüttmannAlessandro MagliKe ShiJohnny KimHideki Aihara Michael Kyba

Published in: bioRxiv : the preprint server for biology (2023)

Platypus sDUX is toxic and inhibits myogenic differentiation.DUXA targets overlap substantially with those of DUX4.DUXA fused to a synthetic transactivation domain acquires DUX4-like toxicity.DUXA behaves as a competitive inhibitor of DUX4.

Keyphrases

transcription factor
protein protein
binding protein
amino acid
small molecule