Hideki Aihara

ORCID

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 45

Top Venues

bioRxiv : the preprint server for biology

Proceedings of the National Academy of Sciences of the United States of America

Biochemistry

Journal of medicinal chemistry

University of Minnesota

University of Tokyo (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Minnesota

United States

Assistant/Associate Professor :: Biochemistry, Molecular Biology, and Biophysics

Education History

University of Tokyo

Japan

PHD :: Biophysics and Biochemistry

Publications

Christopher A Belica, Michael A Carpenter, Yanjun Chen, William L Brown, Nicholas H Moeller, Ian T Boylan, Reuben Stewart Harris, Hideki Aihara
A real-time biochemical assay for quantitative analyses of APOBEC-catalyzed DNA deamination. bioRxiv : the preprint server for biology (2024)
Wei Zhang, Ke Shi, Fu-Chun Hsueh, Alise Mendoza, Gang Ye, Linfen Huang, Stanley Perlman, Hideki Aihara, Fang Li
Structural basis for mouse receptor recognition by bat SARS2-like coronaviruses. Proceedings of the National Academy of Sciences of the United States of America 121 (32) (2024)
Christopher A Belica, Michael A Carpenter, Yanjun Chen, William L Brown, Nicholas H Moeller, Ian T Boylan, Reuben Stewart Harris, Hideki Aihara
A real-time biochemical assay for quantitative analyses of APOBEC-catalyzed DNA deamination. bioRxiv : the preprint server for biology (2024)
Lulu Yin, Ke Shi, Yanjun Chen, Reuben Stewart Harris, Hideki Aihara
Structural basis for sequence context-independent single-stranded DNA cytosine deamination by the bacterial toxin SsdA. bioRxiv : the preprint server for biology (2024)
Wei Zhang, Ke Shi, Fu-Chun Hsueh, Alise Mendoza, Gang Ye, Linfen Huang, Stanley Perlman, Hideki Aihara, Fang Li
Structural basis for mouse receptor recognition by bat SARS2-like coronaviruses. Proceedings of the National Academy of Sciences of the United States of America 121 (32) (2024)
Christopher A Belica, Michael A Carpenter, Yanjun Chen, William L Brown, Nicholas H Moeller, Ian T Boylan, Reuben Stewart Harris, Hideki Aihara
A real-time biochemical assay for quantitative analyses of APOBEC-catalyzed DNA deamination. bioRxiv : the preprint server for biology (2024)
Christopher A Belica, Michael A Carpenter, Yanjun Chen, William L Brown, Nicholas H Moeller, Ian T Boylan, Reuben Stewart Harris, Hideki Aihara
A real-time biochemical assay for quantitative analyses of APOBEC-catalyzed DNA deamination. bioRxiv : the preprint server for biology (2024)
Christopher A Belica, Michael A Carpenter, Yanjun Chen, William L Brown, Nicholas H Moeller, Ian T Boylan, Reuben Stewart Harris, Hideki Aihara
A real-time biochemical assay for quantitative analyses of APOBEC-catalyzed DNA deamination. bioRxiv : the preprint server for biology (2024)
Wei Zhang, Ke Shi, Fu-Chun Hsueh, Alise Mendoza, Gang Ye, Linfen Huang, Stanley Perlman, Hideki Aihara, Fang Li
Structural basis for mouse receptor recognition by bat SARS2-like coronaviruses. Proceedings of the National Academy of Sciences of the United States of America 121 (32) (2024)
Seyed Arad Moghadasi, Emmanuel Heilmann, Ahmed Magdy Khalil, Christina Nnabuife, Fiona L Kearns, Chengjin Ye, Sofia N Moraes, Francesco Costacurta, Morgan A Esler, Hideki Aihara, Dorothee von Laer, Luis Martinez-Sobrido, Timothy G Palzkill, Rommie Elizabeth Amaro, Reuben Stewart Harris
Transmissible SARS-CoV-2 variants with resistance to clinical protease inhibitors. Science advances 9 (13) (2023)
Grant W Larson, Peter K Windsor, Elizabeth Smithwick, Ke Shi, Hideki Aihara, Anoop Rama Damodaran, Ambika Bhagi-Damodaran
Understanding ATP Binding to DosS Catalytic Domain with a Short ATP-Lid. Biochemistry (2023)
Seyed Arad Moghadasi, Emmanuel Heilmann, Ahmed Magdy Khalil, Christina Nnabuife, Fiona L Kearns, Chengjin Ye, Sofia N Moraes, Francesco Costacurta, Morgan A Esler, Hideki Aihara, Dorothee von Laer, Luis Martinez-Sobrido, Timothy G Palzkill, Rommie Elizabeth Amaro, Reuben Stewart Harris
Transmissible SARS-CoV-2 variants with resistance to clinical protease inhibitors. Science advances 9 (13) (2023)
Lulu Yin, Ke Shi, Hideki Aihara
Structural basis of sequence-specific cytosine deamination by double-stranded DNA deaminase toxin DddA. Nature structural & molecular biology (2023)
Darko Bosnakovski, Erik A Toso, Elizabeth T Ener, Micah D Gearhart, Lulu Yin, Felipe F Lüttmann, Alessandro Magli, Ke Shi, Johnny Kim, Hideki Aihara, Michael Kyba
Antagonism among DUX family members evolved from an ancestral toxic single homeodomain protein. bioRxiv : the preprint server for biology (2023)
Lidia K Limón, Ke Shi, Amy Dao, Jacob Rugloski, Kassidy J Tompkins, Hideki Aihara, Wendy R Gordon, Robert L Evans
The crystal structure of the human smacovirus 1 Rep domain. Acta crystallographica. Section F, Structural biology communications (2023)
Darko Bosnakovski, Erik A Toso, Elizabeth T Ener, Micah D Gearhart, Lulu Yin, Felipe F Lüttmann, Alessandro Magli, Ke Shi, Johnny Kim, Hideki Aihara, Michael Kyba
Antagonism among DUX family members evolved from an ancestral toxic single homeodomain protein. bioRxiv : the preprint server for biology (2023)
Darko Bosnakovski, Erik A Toso, Elizabeth T Ener, Micah D Gearhart, Lulu Yin, Felipe F Lüttmann, Alessandro Magli, Ke Shi, Johnny Kim, Hideki Aihara, Michael Kyba
Antagonism among DUX family members evolved from an ancestral toxic single homeodomain protein. bioRxiv : the preprint server for biology (2023)
Seyed Arad Moghadasi, Emmanuel Heilmann, Ahmed Magdy Khalil, Christina Nnabuife, Fiona L Kearns, Chengjin Ye, Sofia N Moraes, Francesco Costacurta, Morgan A Esler, Hideki Aihara, Dorothee von Laer, Luis Martinez-Sobrido, Timothy G Palzkill, Rommie Elizabeth Amaro, Reuben Stewart Harris
Transmissible SARS-CoV-2 variants with resistance to clinical protease inhibitors. Science advances 9 (13) (2023)
Jordan A Naumann, Prokopios P Argyris, Michael A Carpenter, Harshita B Gupta, Yanjun Chen, Nuri A Temiz, Yufan Zhou, Cameron Durfee, Joshua Proehl, Brenda L Koniar, Silvestro Giovanni Conticello, David A Largaespada, William L Brown, Hideki Aihara, Rachel Isaksson Vogel, Reuben S Harris
DNA Deamination Is Required for Human APOBEC3A-Driven Hepatocellular Carcinoma In Vivo. International journal of molecular sciences 24 (11) (2023)
Tianyu He, Tiffany C Edwards, Jiashu Xie, Hideki Aihara, Robert J Geraghty, Zhengqiang Wang
4,5-Dihydroxypyrimidine Methyl Carboxylates, Carboxylic Acids, and Carboxamides as Inhibitors of Human Cytomegalovirus pUL89 Endonuclease. Journal of medicinal chemistry 65 (7) (2022)
Huarui Cui, Anand Divakaran, Zachariah J Hoell, Mikael O Ellingson, Cole R Scholtz, Huda Zahid, Jorden A Johnson, Elizabeth C Griffith, Clifford T Gee, Amani L Lee, Shalil Khanal, Ke Shi, Hideki Aihara, Vijay H Shah, Richard E Lee, Daniel A Harki, William C K Pomerantz
A Structure-based Design Approach for Generating High Affinity BRD4 D1-Selective Chemical Probes. Journal of medicinal chemistry 65 (3) (2022)
Nicholas H Moeller, Ke Shi, Özlem Demir, Christopher Belica, Surajit Banerjee, Lulu Yin, Cameron Durfee, Rommie Elizabeth Amaro, Hideki Aihara
Structure and dynamics of SARS-CoV-2 proofreading exoribonuclease ExoN. Proceedings of the National Academy of Sciences of the United States of America 119 (9) (2022)
Wei Zhang, Ke Shi, Qibin Geng, Gang Ye, Hideki Aihara, Fang Li
Structural basis for mouse receptor recognition by SARS-CoV-2 omicron variant. Proceedings of the National Academy of Sciences of the United States of America 119 (44) (2022)
Nicholas H Moeller, Kellan T Passow, Daniel A Harki, Hideki Aihara
SARS-CoV-2 nsp14 Exoribonuclease Removes the Natural Antiviral 3'-Deoxy-3',4'-didehydro-cytidine Nucleotide from RNA. Viruses 14 (8) (2022)
Krishan K Pandey, Sibes Bera, Ke Shi, Michael J Rau, Amarachi V Oleru, James A J Fitzpatrick, Alan N Engelman, Hideki Aihara, Duane P Grandgenett
Cryo-EM structure of the Rous sarcoma virus octameric cleaved synaptic complex intasome. Communications biology 4 (1) (2021)
Gang Ye, Joseph P Gallant, Jian Zheng, Christopher Massey, Ke Shi, Wanbo Tai, Abby Odle, Molly Vickers, Jian Shang, Yushun Wan, Lanying Du, Hideki Aihara, Stanley Perlman, Aaron LeBeau, Fang Li
The development of Nanosota-1 as anti-SARS-CoV-2 nanobody drug candidates. eLife 10 (2021)
Jason C Jones, Rahul Banerjee, Ke Shi, Manny M Semonis, Hideki Aihara, William C K Pomerantz, John D Lipscomb
Soluble Methane Monooxygenase Component Interactions Monitored by 19F NMR. Biochemistry 60 (25) (2021)
Jason C Jones, Rahul Banerjee, Manny M Semonis, Ke Shi, Hideki Aihara, John D Lipscomb
X-ray Crystal Structures of Methane Monooxygenase Hydroxylase Complexes with Variants of Its Regulatory Component: Correlations with Altered Reaction Cycle Dynamics. Biochemistry 61 (1) (2021)
Ryan M Baxley, Wendy Leung, Megan M Schmit, Jacob Peter Matson, Lulu Yin, Marissa K Oram, Liangjun Wang, John Taylor, Jack Hedberg, Colette B Rogers, Adam J Harvey, Debashree Basu, Jenny C Taylor, Alistair T Pagnamenta, Helene Dreau, Jude Craft, Elizabeth Ormondroyd, Hugh C Watkins, Eric A Hendrickson, Emily M Mace, Jordan S Orange, Hideki Aihara, Grant S Stewart, Edward Blair, Jeanette Gowen Cook, Anja-Katrin Bielinsky
Bi-allelic MCM10 variants associated with immune dysfunction and cardiomyopathy cause telomere shortening. Nature communications 12 (1) (2021)
Ke Shi, Nicholas H Moeller, Surajit Banerjee, Jennifer L McCann, Michael A Carpenter, Lulu Yin, Ramkumar Moorthy, Kayo Orellana, Daniel A Harki, Reuben Stewart Harris, Hideki Aihara
Structural basis for recognition of distinct deaminated DNA lesions by endonuclease Q. Proceedings of the National Academy of Sciences of the United States of America 118 (10) (2021)
Obinna C Ubah, Eric W Lake, Gihan S Gunaratne, Joseph P Gallant, Marie Fernie, Austin J Robertson, Jonathan S Marchant, Tyler D Bold, Ryan A Langlois, William E Matchett, Joshua M Thiede, Ke Shi, Lulu Yin, Nicholas H Moeller, Surajit Banerjee, Laura Ferguson, Marina Kovaleva, Andrew J Porter, Hideki Aihara, Aaron M LeBeau, Caroline J Barelle
Mechanisms of SARS-CoV-2 neutralization by shark variable new antigen receptors elucidated through X-ray crystallography. Nature communications 12 (1) (2021)
Huda Zahid, Caroline R Buchholz, Manjulata Singh, Michael F Ciccone, Alice Chan, Stanley Nithianantham, Ke Shi, Hideki Aihara, Marcus Fischer, Ernst K Schonbrunn, Camila O Dos Santos, Joseph W Landry, William C K Pomerantz
New Design Rules for Developing Potent Cell-Active Inhibitors of the Nucleosome Remodeling Factor (NURF) via BPTF Bromodomain Inhibition. Journal of medicinal chemistry 64 (18) (2021)
Heng Tang, Özlem Demir, Fredy Kurniawan, William L Brown, Ke Shi, Nicholas H Moeller, Michael A Carpenter, Christopher Belica, Kayo Orellana, Guocheng Du, Aaron M LeBeau, Rommie E Amaro, Reuben S Harris, Hideki Aihara
Structural Characterization of a Minimal Antibody against Human APOBEC3B. Viruses 13 (4) (2021)
Huarui Cui, Angela S Carlson, Mary A Schleiff, Anand Divakaran, Jorden A Johnson, Caroline R Buchholz, Huda Zahid, Nora R Vail, Ke Shi, Hideki Aihara, Daniel A Harki, Grover P Miller, Joseph J Topczewski, William C K Pomerantz
4-Methyl-1,2,3-Triazoles as N-Acetyl-Lysine Mimics Afford Potent BET Bromodomain Inhibitors with Improved Selectivity. Journal of medicinal chemistry 64 (14) (2021)
Jian Shang, Gang Ye, Ke Shi, Yushun Wan, Chuming Luo, Hideki Aihara, Qibin Geng, Ashley Auerbach, Fang Li
Structural basis of receptor recognition by SARS-CoV-2. Nature 581 (7807) (2020)
Ke Shi, Fredy Kurniawan, Surajit Banerjee, Nicholas H Moeller, Hideki Aihara
Crystal structure of bacteriophage T4 Spackle as determined by native SAD phasing. Acta crystallographica. Section D, Structural biology 76 (Pt 9) (2020)
Jason C Jones, Rahul Banerjee, Ke Shi, Hideki Aihara, John D Lipscomb
Structural Studies of the Methylosinus trichosporium OB3b Soluble Methane Monooxygenase Hydroxylase and Regulatory Component Complex Reveal a Transient Substrate Tunnel. Biochemistry 59 (32) (2020)
Ke Shi, Justin T Oakland, Fredy Kurniawan, Nicholas H Moeller, Surajit Banerjee, Hideki Aihara
Structural basis of superinfection exclusion by bacteriophage T4 Spackle. Communications biology 3 (1) (2020)
Gang Ye, Joseph P Gallant, Christopher Massey, Ke Shi, Wanbo Tai, Jian Zheng, Abby E Odle, Molly A Vickers, Jian Shang, Yushun Wan, Aleksandra Drelich, Kempaiah R Kempaiah, Vivian Tat, Stanley Perlman, Lanying Du, Chien-Te Tseng, Hideki Aihara, Aaron M LeBeau, Fang Li
The Development of a Novel Nanobody Therapeutic for SARS-CoV-2. bioRxiv : the preprint server for biology (2020)
Na Li, Ke Shi, Timsi Rao, Surajit Banerjee, Hideki Aihara
Structural insights into the promiscuous DNA binding and broad substrate selectivity of fowlpox virus resolvase. Scientific reports 10 (1) (2020)
Veer Bhatt, Ke Shi, Daniel J Salamango, Nicholas H Moeller, Krishan K Pandey, Sibes Bera, Heather O Bohl, Fredy Kurniawan, Kayo Orellana, Wei Zhang, Duane P Grandgenett, Reuben Stewart Harris, Anna C Sundborger-Lunna, Hideki Aihara
Structural basis of host protein hijacking in human T-cell leukemia virus integration. Nature communications 11 (1) (2020)
Ke Shi, Seunghee Cho, Kelly G Aukema, Thomas Lee, Asim K Bera, Jennifer L Seffernick, Lawrence P Wackett, Hideki Aihara
Crystal structures of Moorella thermoacetica cyanuric acid hydrolase reveal conformational flexibility and asymmetry important for catalysis. PloS one 14 (6) (2019)
Jayakanth Kankanala, Carlos J A Ribeiro, Evgeny Kiselev, Azhar Ravji, Jessica Williams, Jiashu Xie, Hideki Aihara, Yves Pommier, Zhengqiang Wang
Novel Deazaflavin Analogues Potently Inhibited Tyrosyl DNA Phosphodiesterase 2 (TDP2) and Strongly Sensitized Cancer Cells toward Treatment with Topoisomerase II (TOP2) Poison Etoposide. Journal of medicinal chemistry 62 (9) (2019)
Maksim V Kvach, Fareeda M Barzak, Stefan Harjes, Henry A M Schares, Geoffrey B Jameson, Alex M Ayoub, Ramkumar Moorthy, Hideki Aihara, Reuben S Harris, Vyacheslav V Filichev, Daniel A Harki, Elena Harjes
Inhibiting APOBEC3 Activity with Single-Stranded DNA Containing 2'-Deoxyzebularine Analogues. Biochemistry 58 (5) (2018)
Hideki Aihara, Ke Shi, John K Lee, Darko Bosnakovski, Michael Kyba
Comment on structural basis of DUX4/IGH-driven transactivation. Leukemia 32 (9) (2018)

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Publication Activity (10 Years)

Top Topics

Top Venues

Hideki Aihara