In Vitro Lipid Overload Affects Cellular Proliferation, Apoptosis, and Senescence in a Time-Dependent Manner in HepG2 Hepatocytes and LX-2 Hepatic Stellate Cells.
Adriana Campos-EspinosaCarolina GuzmánKarla Zaira Medina-ÁvilaGabriela Gutierrez-ReyesPublished in: Cells (2024)
Lipid overload induces differential effects depending on the cell type, the steatogenic input level, and the exposure time. Hepatocytes are resilient to mild steatosis but susceptible to high lipotoxicity. HSCs are sensitive to lipid overload, undergoing apoptosis and lowering senescence and proliferation. Collectively, these data may help explain the development of steatosis and fibrosis in SLD.
Keyphrases
- cell cycle arrest
- endoplasmic reticulum stress
- induced apoptosis
- cell death
- oxidative stress
- signaling pathway
- pi k akt
- dna damage
- insulin resistance
- fatty acid
- high fat diet
- endothelial cells
- liver injury
- electronic health record
- stress induced
- big data
- metabolic syndrome
- adipose tissue
- type diabetes
- artificial intelligence
- drug induced
- liver fibrosis