Docosahexaenoic Acid (DHA) Reduces LPS-Induced Inflammatory Response Via ATF3 Transcription Factor and Stimulates Src/Syk Signaling-Dependent Phagocytosis in Microglia.
Katarzyna Wieczorek-SzukalaMonika MarkiewiczAnna WalczewskaEmilia ZgorzynskaPublished in: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology (2023)
These findings indicate that DHA efficiently inhibits ATF3-dependent release of proinflammatory mediators and enhances phagocytic activity of microglia. The study provides a new mechanism of DHA action in reactive microglia, which may help limit neuronal damage caused by the pro-inflammatory milieu in the brain.
Keyphrases
- inflammatory response
- lps induced
- transcription factor
- fatty acid
- lipopolysaccharide induced
- toll like receptor
- tyrosine kinase
- endoplasmic reticulum stress
- dna binding
- cerebral ischemia
- oxidative stress
- white matter
- resting state
- neuropathic pain
- spinal cord
- blood brain barrier
- genome wide identification
- functional connectivity