Bellidifolin Inhibits Proliferation of A549 Cells by Regulating STAT3/COX-2 Expression and Protein Activity.

Li YanLuo YaliLi ChenghaoFeng CaiqinZhu ZhongboRen WeiyuMa YuZhou XiaotianWang BiwenXiaojie Jin Yong-Qi Liu

Published in: Journal of oncology (2020)

Based on a series of in vitro analyses, network pharmacology, and molecular docking, the potential mechanism involving the antiproliferative and cytotoxic effects of BEL in lung cancer cells was investigated. Our study may help providing some theoretical basis for the discovery of novel phytotherapy drugs applicable for the treatment of lung cancer.

Keyphrases

molecular docking
induced apoptosis
molecular dynamics simulations
poor prognosis
small molecule
cell cycle arrest
binding protein
cell proliferation
high throughput
endoplasmic reticulum stress
signaling pathway
combination therapy
high resolution
climate change
risk assessment
single cell
drug induced