Fibro-inflammatory recovery and type 2 diabetes remission following a low calorie diet but not exercise training: A secondary analysis of the DIASTOLIC randomised controlled trial.
Emer M BradyGaurav S GulsinEvgeny M MirkesKelly ParkePrathap KanagalaLeong L NgMatthew P M Graham-BrownLavanya AthithanJoseph HensonEmma RedmanJang YangLei ZhaoStavroula ArgyridouLaura J GrayThomas YatesMelanie Jane DaviesGerry P McCannPublished in: Diabetic medicine : a journal of the British Diabetic Association (2022)
Fibro-inflammatory pathways and cardiovascular structure/function are adversely altered before the onset of symptomatic CVD in middle-aged adults with T2D. The MRP improved the fibro-inflammatory profile of people with T2D towards a more healthy status. Long-term studies are required to assess whether these changes lead to continued reverse cardiac remodelling and prevent CVD.
Keyphrases
- type diabetes
- middle aged
- oxidative stress
- left ventricular
- weight loss
- study protocol
- blood pressure
- skeletal muscle
- physical activity
- cardiovascular disease
- heart failure
- clinical trial
- randomized controlled trial
- glycemic control
- rheumatoid arthritis
- adipose tissue
- ejection fraction
- disease activity
- atrial fibrillation