A Potential Role for MAGI-1 in the Bi-Directional Relationship Between Major Depressive Disorder and Cardiovascular Disease.
Priyanka BanerjeeKhanh ChauSivareddy KotlaEleanor L DavisEstefani Berrios TurciosShengyu LiZhang PengzhiGuangyu WangGopi Krishna KolluruAbhishek JainJohn P CookeJunichi AbeNhat-Tu LePublished in: Current atherosclerosis reports (2024)
Single nucleotide polymorphisms (SNPs) in the membrane-associated guanylate kinase WW and PDZ domain-containing protein 1 (MAGI-1) are associated with neuroticism and psychiatric disorders including MDD. SNPs in MAGI-1 are also linked to chronic inflammatory disorders such as spontaneous glomerulosclerosis, celiac disease, ulcerative colitis, and Crohn's disease. Increased MAGI-1 expression has been observed in colonic epithelial samples from Crohn's disease and ulcerative colitis patients. MAGI-1 also plays a role in regulating EC activation and atherogenesis in mice and is essential for Influenza A virus (IAV) infection, endoplasmic reticulum stress-induced EC apoptosis, and thrombin-induced EC permeability. Despite being understudied in human disease; evidence suggests that MAGI-1 may play a role in linking CVD and MDD. Therefore, further investigation of MAG-1 could be warranted to elucidate its potential involvement in these conditions.
Keyphrases
- major depressive disorder
- ulcerative colitis
- stress induced
- bipolar disorder
- cardiovascular disease
- endoplasmic reticulum
- endothelial cells
- celiac disease
- end stage renal disease
- oxidative stress
- newly diagnosed
- poor prognosis
- type diabetes
- ejection fraction
- cell death
- high glucose
- drug induced
- chronic kidney disease
- gene expression
- peritoneal dialysis
- diabetic rats
- prognostic factors
- cardiovascular risk factors
- coronary artery disease
- cardiovascular events