C-Glycosylation enabled by N-(glycosyloxy)acetamides.
Miao LiuBo-Han LiTian LiXia WuMeng LiuDe-Cai XiongXin-Shan YePublished in: Organic & biomolecular chemistry (2020)
The C-glycosylation of C-nucleophiles including allyltrimethylsilane, silyl enol ethers and phenols with N-(glycosyloxy)acetamides as glycosyl donors has been realized. This protocol provides a convenient and practical route for the synthesis of alkyl C-glycosides and aryl 2-deoxy-β-C-glycosides under mild reaction conditions.