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Nucleophilic Functionalizations of Aniline Derivatives: Aromatic Pummerer Reaction for Umpolung Halogenation and Hydroxylation on Benzene Ring.

Xingping BaoJinzhong YaoHongwei ZhouGuangyu Xu
Published in: Organic letters (2018)
In this paper, a metal-free protocol of nucleophilic ortho-halogenation and hydroxylation of anilines via an aromatic Pummerer process is reported.
Keyphrases
  • amino acid
  • randomized controlled trial
  • structure activity relationship