Nuclear blebs are associated with destabilized chromatin packing domains.
Emily M PujadasNicolas AcostaLuay Matthew AlmassalhaYuanzhe Patrick SuRuyi GongMasato T KanemakiAndrew D StephensVadim BackmanPublished in: bioRxiv : the preprint server for biology (2024)
Nuclear blebs are linked to various pathologies, including cancer and premature aging disorders. We investigate alterations in higher-order chromatin structure within blebs, revealing fragmentation of nanoscopic heterochromatin domains.