Id-neoantigen vaccine induces therapeutic CD8 + T cells against multiple myeloma: H chain-loss escapees cause FLC MM.

Marita WesthrinJana BlazevskiAna TextorPegah AbdollahiRamakrishna Prabhu GopalakrishnanLinda Thuy NgoPeter Olaf HofgaardJulia HeinzelbeckerSonja BobicEven FossumHeidi Cecilie Larsen SpångRanveig BraathenBjarne Bogen

Published in: Journal for immunotherapy of cancer (2023)

T cells elicited by CCL3-containing Id vaccines had a therapeutic effect against MM in a mouse model. MM cells could escape rejection by losing expression of the H chain, thus giving rise to FLC MM.

Keyphrases

mouse model
multiple myeloma
induced apoptosis
poor prognosis
cell cycle arrest
long non coding rna
liver fibrosis
drug induced