Obesity-related glomerulopathy is associated with elevated WT1 expression in podocytes.

Sneha JakhotiaRajesh KavvuriSumathi RavirajSomorita BaishyaAnil Kumar Pasupulati Geereddy Bhanuprakash Reddy

Published in: International journal of obesity (2005) (2024)

WT1 is crucial during nephron development and has minimal expression in adult podocytes. Our study discovered elevated expression of WT1 in podocytes in obesity settings. Our analysis suggests a novel function for WT1 in the pathogenesis of ORG; however, the precise mechanism of WT1 induction and its involvement in podocyte pathobiology needs further investigation.

Keyphrases

poor prognosis
diabetic nephropathy
high glucose
metabolic syndrome
insulin resistance
type diabetes
weight loss
binding protein
weight gain
high fat diet induced
long non coding rna
endothelial cells
physical activity