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MicroRNA-512-3p mediates Trypanosoma cruzi-induced apoptosis during ex vivo infection of human placental explants.

Jesús Guerrero-MuñozLisvaneth MedinaChristian CastilloAna LiempiAlejandro Fernández-MoyaSebastian AranedaYessica OrtegaMaura Rojas-PirelaJuan Diego MayaUlrike Kemmerling
Published in: Placenta (2023)
Our findings suggest that miR-512-3p modulates parasite-induced apoptosis in the trophoblast. By understanding the mechanisms involved in this process, we can gain insights into the pathogenesis of congenital Chagas disease and develop targeted therapeutic strategies.
Keyphrases
  • induced apoptosis
  • trypanosoma cruzi
  • endoplasmic reticulum stress
  • signaling pathway
  • oxidative stress
  • endothelial cells
  • induced pluripotent stem cells
  • pluripotent stem cells
  • toxoplasma gondii