MicroRNA-512-3p mediates Trypanosoma cruzi-induced apoptosis during ex vivo infection of human placental explants.
Jesús Guerrero-MuñozLisvaneth MedinaChristian CastilloAna LiempiAlejandro Fernández-MoyaSebastian AranedaYessica OrtegaMaura Rojas-PirelaJuan Diego MayaUlrike KemmerlingPublished in: Placenta (2023)
Our findings suggest that miR-512-3p modulates parasite-induced apoptosis in the trophoblast. By understanding the mechanisms involved in this process, we can gain insights into the pathogenesis of congenital Chagas disease and develop targeted therapeutic strategies.