Chloroquine attenuates TLR3-mediated plasminogen activator inhibitor-1 expression in cultured human glomerular endothelial cells.

Tomomi AizawaTadaatsu ImaizumiKoji HironoShojiro WatanabeKoji TsugawaHiroshi Tanaka

Published in: Clinical and experimental nephrology (2018)

Considering that TLR3 signaling is implicated in LN pathogenesis, our results suggest that chloroquine exert postulated renoprotective effects by inhibiting PAI-1 expression.

Keyphrases

endothelial cells
poor prognosis
high glucose
toll like receptor
inflammatory response
immune response
vascular endothelial growth factor
binding protein
signaling pathway
long non coding rna
diabetic nephropathy
nuclear factor
induced pluripotent stem cells