Potential Protective and Therapeutic Roles of the Nrf2 Pathway in Ocular Diseases: An Update.
Ming-Xuan WangJing ZhaoHong ZhangKe LiLing-Zhi NiuYuan-Ping WangYa-Juan ZhengPublished in: Oxidative medicine and cellular longevity (2020)
Nuclear factor- (erythroid-derived 2-) like 2 (Nrf2) is a regulator of many processes of life, and it plays an important role in antioxidant, anti-inflammatory, and antifibrotic responses and in cancer. This review is focused on the potential mechanism of Nrf2 in the occurrence and development of ocular diseases. Also, several Nrf2 inducers, including noncoding RNAs and exogenous compounds, which control the expression of Nrf2 through different pathways, are discussed in ocular disease models and ocular cells, protecting them from dysfunctional changes. Therefore, Nrf2 might be a potential target of protecting ocular cells from various stresses and preventing ocular diseases.
Keyphrases
- oxidative stress
- nuclear factor
- induced apoptosis
- anti inflammatory
- optic nerve
- poor prognosis
- toll like receptor
- risk assessment
- immune response
- human health
- transcription factor
- signaling pathway
- cell cycle arrest
- cell death
- papillary thyroid
- endoplasmic reticulum stress
- young adults
- binding protein
- lymph node metastasis