Hemangiosarcoma Cells Promote Conserved Host-derived Hematopoietic Expansion.

Jong Hyuk Kim Ashley J Schulte Aaron L Sarver Donghee Lee Mathew G Angelos Aric M Frantz Colleen L Forster Timothy D O'Brien Ingrid Cornax M Gerard O'Sullivan Nuojin Cheng Mitzi Lewellen LeAnn Oseth Sunil Kumar Mor Susan Bullman Chandra Sekhar Pedamallu Sagar M Goyal Matthew L Meyerson Troy C Lund Matthew Breen Kerstin Lindblad-Toh Erin B Dickerson Dan S Kaufman Jaime F Modiano

Published in: Cancer research communications (2024)

We demonstrate that hemangiosarcomas regulate molecular programs supporting hematopoietic expansion and differentiation, providing insights into their potential roles in creating a permissive stromal-immune environment for tumor progression.

Keyphrases

bone marrow
induced apoptosis
cell cycle arrest
public health
poor prognosis
transcription factor
cell death
oxidative stress
human health
long non coding rna
single molecule
risk assessment
climate change