We concluded that expression changes of lncRNAs exists in the microenvironment of denervated hippocampus, of which promotes hippocampal neurogenesis. The identified lncRNA lncRNA2393 expressed in neural stem cells, located in the subgranular zone of the dentate gyrus, which can promote NSCs proliferation in vitro. Therefore, the question is exactly which part of the denervated hippocampus induced the expression of lncRNA2393. Further studies should aim to explore the exact molecular mechanism behind the expression of lncRNA2393 in the hippocampus, to lay the foundation for the clinical application of NSCs in treating diseases of the central nervous system.
Keyphrases
- cerebral ischemia
- poor prognosis
- neural stem cells
- long non coding rna
- long noncoding rna
- cognitive impairment
- subarachnoid hemorrhage
- prefrontal cortex
- binding protein
- blood brain barrier
- gene expression
- high glucose
- oxidative stress
- cerebrospinal fluid
- endothelial cells
- transcription factor
- bioinformatics analysis