Anti- and Pro-Oxidant Properties of Essential Oils against Antimicrobial Resistance.
Amanda Shen-Yee KongSathiya MaranPolly Soo-Xi YapSwee-Hua Erin LimShun-Kai YangWan-Hee ChengYong-Hui TanKok-Song LaiPublished in: Antioxidants (Basel, Switzerland) (2022)
The rapid evolution of antimicrobial resistance (AMR) has remained a major public health issue, reducing the efficacy of antibiotics and increasing the difficulty of treating infections. The discovery of novel antimicrobial agents is urgently needed to overcome the challenges created by AMR. Natural products such as plant extracts and essential oils (EOs) have been viewed as potential candidates to combat AMR due to their complex chemistry that carries inherent pro-oxidant and antioxidant properties. EOs and their constituents that hold pro-oxidant properties can induce oxidative stress by producing reactive oxygen species (ROS), leading to biological damage in target cells. In contrast, the antioxidant properties scavenge free radicals through offsetting ROS. Both pro-oxidant and antioxidant activities in EOs represent a promising strategy to tackle AMR. Thus, this review aimed to discuss how pro-oxidants and antioxidants in EOs may contribute to the mitigation of AMR and provided a detailed description of the challenges and limitations of utilizing them as a means to combat AMR.
Keyphrases
- anti inflammatory
- antimicrobial resistance
- oxidative stress
- reactive oxygen species
- public health
- induced apoptosis
- dna damage
- cell death
- climate change
- small molecule
- magnetic resonance
- magnetic resonance imaging
- ischemia reperfusion injury
- computed tomography
- human health
- risk assessment
- global health
- quantum dots