Cupressus arizonica Greene: Phytochemical Profile and Cosmeceutical and Dermatological Properties of Its Leaf Extracts.
Nora TawfeekEman FikryIsmail MahdiMelvin Adhiambo OchiengWidad Ben BakrimNoamane TaarjiMona F MahmoudMansour SobehPublished in: Molecules (Basel, Switzerland) (2023)
For many decades, natural resources have traditionally been employed in skin care. Here, we explored the phytochemical profile of the aqueous and ethanolic leaf extracts of Cupressus arizonica Greene and assessed their antioxidant, antiaging and antibacterial activities in vitro. Liquid chromatography-mass spectrometry (LC-MS/MS) analysis led to the tentative identification of 67 compounds consisting mainly of phenolic and fatty acids, diterpene acids, proanthocyanidins and flavonoid and biflavonoid glycosides. The aqueous extract demonstrated substantial in vitro antioxidant potential at FRAP and DPPH assays and inhibited the four target enzymes (collagenase, elastase, tyrosinase, and hyaluronidase) engaged in skin remodeling and aging with IC 50 values close to those of the standard drugs. Moreover, the aqueous extract at 25 mg/mL suppressed biofilm formation by Pseudomonas aeruginosa , a bacterial pathogen causing common skin manifestations, and decreased its swarming and swimming motilities. In conclusion, C. arizonica leaves can be considered a promising candidate for potential application in skin aging.
Keyphrases
- pseudomonas aeruginosa
- biofilm formation
- mass spectrometry
- liquid chromatography
- wound healing
- soft tissue
- oxidative stress
- anti inflammatory
- candida albicans
- ionic liquid
- staphylococcus aureus
- fatty acid
- healthcare
- escherichia coli
- human health
- risk assessment
- climate change
- simultaneous determination
- quality improvement
- capillary electrophoresis
- drug induced
- acinetobacter baumannii
- hyaluronic acid
- pain management