Probiotic Lactobacillus rhamnosus GG Prevents Liver Fibrosis Through Inhibiting Hepatic Bile Acid Synthesis and Enhancing Bile Acid Excretion in Mice.
Yunhuan LiuKefei ChenFengyuan LiZelin GuQi LiuLiqing HeTuo ShaoQing SongFenxia ZhuLihua ZhangMengwei JiangYun ZhouShirish BarveXiang ZhangCraig J McClainWenke FengPublished in: Hepatology (Baltimore, Md.) (2020)
LGG supplementation decreases hepatic BA by increasing intestinal FXR-FGF-15 signaling pathway-mediated suppression of BA de novo synthesis and enhances BA excretion, which prevents excessive BA-induced liver injury and fibrosis in mice.