Induction of MMP-3 and MMP-9 expression during Helicobacter pylori infection via MAPK signaling pathways.

Ioannis KarayiannisBeatriz Martinez-GonzalezEleftherios KontizasAndroniki Voulgari KokkotaKalliopi PetrakiAndreas MentisPanagoula KolliaDionyssios Nicholas Sgouras

Published in: Helicobacter (2023)

H. pylori colonization leads to the upregulation of MMP-3 and MMP-9 in vivo, which primarily involves ERK1/2 and JNK pathways. Therefore, their inhibition may potentially offer a protective effect against gastric carcinogenesis and metastasis.

Keyphrases

signaling pathway
helicobacter pylori infection
pi k akt
cell migration
poor prognosis
induced apoptosis
cell proliferation
epithelial mesenchymal transition
oxidative stress
cell death
binding protein