Defective INPP5E distribution in NPHP1-related Senior-Loken syndrome.

Ke NingEmilie SongBrent E SendayenPhilipp P ProssedaKun-Che ChangAlireza GhaffariehJorge A AlvaradoBiao WangKathryn M HaiderNicolas F BerbariYang HuYang Sun

Published in: Molecular genetics & genomic medicine (2020)

The decreased expression of INPP5E specifically in the primary cilium, coupled with disorganized cilia morphology, suggests a novel role of NPHP1 that it is involved in regulating ciliary phosphoinositide composition in the ciliary membrane of renal tubular cells.

Keyphrases

induced apoptosis
poor prognosis
cell cycle arrest
case report
endoplasmic reticulum stress
signaling pathway
cell death
oxidative stress
high glucose
pi k akt
drug induced