Epithelial CST1 Promotes Airway Eosinophilic Inflammation in Asthma via the AKT Signaling Pathway.
Lijuan DuChangyi XuKun TangJia ShiLu TangLisha XiaoChengcheng LeiHuicong LiuYuxia LiangYubiao GuoPublished in: Allergy, asthma & immunology research (2023)
Increased sputum CST1 may play a key role in the pathogenesis of asthma through involvement in eosinophilic and type 2 inflammation through activation of the AKT signaling pathway, further promoting SERPINB2 expression. Therefore, targeting CST1 might be of therapeutic value in treating asthma with severe and eosinophilic phenotypes.
Keyphrases
- signaling pathway
- chronic obstructive pulmonary disease
- lung function
- pi k akt
- oxidative stress
- allergic rhinitis
- chronic rhinosinusitis
- induced apoptosis
- cystic fibrosis
- epithelial mesenchymal transition
- cell proliferation
- poor prognosis
- mycobacterium tuberculosis
- cancer therapy
- air pollution
- early onset
- pulmonary tuberculosis
- drug delivery