Molecular profiling of rheumatoid arthritis patients reveals an association between innate and adaptive cell populations and response to anti-tumor necrosis factor.
Victor FarutinThomas Prod'hommeKevin McConnellNathaniel WashburnPatrick HalveyCarol J EtzelJamey GuessJay DuffnerKristen GetchellRobin MeccarielloBryan GutierrezChristopher HonanGanlin ZhaoNicholas A CilfoneNur Sibel GunayJan L HillsonDavid S DeLucaKatherine C SaundersDimitrios A PappasJeffrey D GreenbergJoel M KremerAnthony M ManningLeona E LingIshan CapilaPublished in: Arthritis research & therapy (2019)
Differences in innate/adaptive immune cell type composition at baseline may be a major contributor to response to anti-TNF treatment within the first 3 months of therapy.