A Low-Dose 4F-PCC Protocol for DOAC-Associated Intracranial Hemorrhage.

Karen BergerMelissa SantibañezLina LinChristine A Lesch

Published in: Journal of intensive care medicine (2019)

The use of a lower dose protocol of 25 units/kg of 4F-PCC resulted in high rates of hemostasis in patients with DOAC-associated ICH. Two patients developed thrombotic events within 14 days of 4F-PCC administration.

Keyphrases

low dose
randomized controlled trial
end stage renal disease
ejection fraction
newly diagnosed
direct oral anticoagulants
high dose
prognostic factors
atrial fibrillation
patient reported