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The effects of inhaled corticosteroids on healthy airways.

Emanuele MarchiTimothy Stopford Christopher HinksMatthew RichardsonLatifa KhalfaouiFiona A SymonPoojitha RajasekarRachel L CliffordBeverley HargadonCary D AustinJulia L MacIsaacMichael S KoborSalman SiddiquiJordan S MarJoseph R ArronDavid F ChoyPeter Bradding
Published in: Allergy (2024)
In healthy airways, 4-week ICS exposure reduces gene expression related to both innate and adaptive immunity, and reduces markers of type-2 inflammation. This implies that homeostasis in health involves tonic type-2 signalling in the airway mucosa, which is exquisitely sensitive to ICS.
Keyphrases
  • cystic fibrosis
  • gene expression
  • immune response
  • healthcare
  • public health
  • oxidative stress
  • dna methylation
  • mental health
  • randomized controlled trial
  • risk assessment
  • human health
  • climate change
  • social media