Beta-blocker initiation under dobutamine infusion in acute advanced heart failure: a target trial emulation with observational data.
Yuichiro MoriKosuke InoueHiroyuki SatoTakahiro TsushimaShingo FukumaPublished in: European heart journal open (2024)
The present observational study emulating a pragmatic RCT found no positive or negative association between beta-blocker initiation under dobutamine infusion and overall survival.
Keyphrases
- heart failure
- study protocol
- low dose
- liver failure
- angiotensin converting enzyme
- clinical trial
- respiratory failure
- electronic health record
- phase iii
- left ventricular
- phase ii
- randomized controlled trial
- free survival
- atrial fibrillation
- cardiac resynchronization therapy
- open label
- intensive care unit
- angiotensin ii
- machine learning
- deep learning